Lymphocyte Immunization Therapy
At Eva IVF & Women’s Centre, we understand that recurrent pregnancy loss (RPL) and implantation failure can be devastating for couples trying to conceive. Lymphocyte Immunization Therapy (LIT) is an immunotherapy treatment designed to help women with immune-related infertility by improving their immune tolerance towards the developing embryo.
LIT is a promising option for women with unexplained recurrent miscarriages, multiple IVF failures, or immune system abnormalities that prevent successful implantation. It works by using the male partner’s white blood cells (lymphocytes) to stimulate the woman’s immune system, helping her body accept and support pregnancy.
This guide is specifically for couples considering LIT as part of their fertility treatment. We’ll walk you through the procedure, who needs it, success rates, and benefits to help you make an informed decision.
What is Lymphocyte Immunization Therapy (LIT), and Who Needs It?
Lymphocyte Immunization Therapy (LIT) is an immunotherapy treatment in which white blood cells (lymphocytes) from the male partner or donor are injected into the female partner to help regulate her immune response to pregnancy.
Who Should Consider LIT?
✔ Women with Recurrent Pregnancy Loss (RPL) Due to Immune Issues
✔ Women Who Have Experienced Multiple IVF Failures Despite Healthy Embryos
✔ Women Diagnosed with High Natural Killer (NK) Cell Activity in the Uterus
✔ Women with Abnormal Immune Responses That Attack Embryos
✔ Couples with Immunological Incompatibility Leading to Failed Implantation
✔ Women with Unexplained Infertility Suspected to Have Immune-Related Causes
💡 LIT helps prevent the maternal immune system from rejecting the developing embryo, allowing for a healthy pregnancy.
How Does Lymphocyte Immunization Therapy Work? (Step-by-Step Process)
1. Male Partner’s Blood Collection & Processing
✔ The lymphocytes are separated from other blood components using a specialized lab process.
2. Lymphocyte Injection into the Female Partner
✔ This stimulates the maternal immune system to recognize the pregnancy as "self" rather than foreign, reducing the risk of rejection.
3. Immune System Response & Monitoring
✔ Follow-up blood tests track immune system changes over the next few weeks.
4. Booster LIT Sessions (If Required)
💡 LIT helps regulate the immune system, reducing miscarriage risk and improving implantation rates.
Success Rates of Lymphocyte Immunization Therapy
📊 How Effective is LIT for Pregnancy Success?
✔ 50-80% pregnancy success rate in women with recurrent pregnancy loss (RPL).
✔ 40-70% success rate in women with multiple IVF failures due to immune rejection.
✔ Significant improvement in live birth rates when combined with IVF or IUI.
✔ Reduction in Natural Killer (NK) cell activity, improving implantation chances.
💡 LIT is one of the most effective treatments for women with immune-related pregnancy complications.
Who is NOT Suitable for LIT?
❌ Women with Autoimmune Diseases That May Be Aggravated by LIT (e.g., Lupus, Rheumatoid Arthritis)
❌ Women with Other Diagnosed Causes of Infertility (e.g., Severe Endometriosis, Tubal Blockage, Genetic Disorders)
❌ Couples Without Any History of Pregnancy Loss or Failed Implantation
💡 A fertility specialist will assess your immune profile before recommending LIT.
Benefits of LIT – Why Choose This Treatment?
🌟 Improves Immune Tolerance Toward the Fetus – Reduces the risk of maternal immune rejection.
🌟 Increases Pregnancy Success in Women with Immune-Related Infertility.
🌟 Reduces Natural Killer (NK) Cell Overactivity, Improving Embryo Implantation.
🌟 Enhances IVF & IUI Success Rates by Creating a More Receptive Uterine Environment.
🌟 Safe, Natural, and Uses the Body’s Own Immune System to Support Pregnancy.
💡 LIT is a powerful immunotherapy solution for women who have experienced repeated pregnancy losses or IVF failures.
Pre-Treatment Preparation – How to Maximize LIT Effectiveness?
✔ Follow a Diet That Supports Immune Balance (Leafy Greens, Omega-3s, Probiotics)
✔ Take Immune-Boosting Supplements (Vitamin D, Zinc, Selenium, CoQ10)
✔ Avoid Smoking, Alcohol, and Excessive Caffeine to Prevent Inflammation
✔ Reduce Stress with Yoga, Meditation, and Adequate Sleep
✔ Discuss Any Previous Immune Disorders with Your Fertility Specialist
💡 Optimizing immune health before LIT can improve treatment effectiveness and pregnancy success.
Post-Treatment Care – What Happens After LIT?
✔ Monitor Antibody Levels to Track the Immune System Response.
✔ Proceed with Natural Conception, IUI, or IVF as Advised by Your Doctor.
✔ Repeat LIT Sessions (if needed) Before Embryo Transfer or Early Pregnancy.
✔ Avoid Immunosuppressive Medications Without Consulting Your Doctor.
✔ Continue Prenatal Vitamins and a Healthy Lifestyle to Support Pregnancy.
💡 Most women see immune improvements within 4-6 weeks of LIT, increasing their chances of a healthy pregnancy.